The Longevity Supplement Knowledge Base

250–500mg/day NAD+ ↑38% Morning

NMN

#1 Most Researched

Nicotinamide Mononucleotide — the leading NAD+ precursor for anti-aging, energy, and cellular repair. 47 human trials.

169 articles Explore →

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CoQ10 / Ubiquinol

Mitochondrial electron transport, heart health, and statin side-effect management

100–400mg/day With fat

4 articles

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PQQ

Pyrroloquinoline quinone — promotes mitochondrial biogenesis and neuroprotection

20mg/day

Senolytics & Cellular Cleanup

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Fisetin

Powerful flavonoid senolytic — clears senescent cells to extend healthspan

Quercetin

Senolytic flavonoid for clearing aged cells, often combined with Dasatinib

Spermidine

Autophagy activator for cellular renewal — found in wheat germ and aged cheese

1–5mg/day

4 articles

Sirtuin Activators & Longevity Pathways

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Resveratrol

Trans-resveratrol activates SIRT1 sirtuins — taken by David Sinclair daily

Berberine

AMPK activator — metabolic health, blood sugar control, often called "nature's metformin"

TMG (Betaine)

Methyl donor — replenishes methylation consumed by NMN, essential co-supplement

500mg/day

Brain, Cognition & Neuroprotection

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Lion's Mane

Hericium erinaceus — stimulates NGF for nerve growth and cognitive enhancement

Omega-3 / Fish Oil

EPA & DHA for brain structure, cardiovascular health, and systemic inflammation

Medicinal Mushrooms

Reishi, Chaga, Turkey Tail — immune modulation, adaptogenic, antioxidant

Varies by species

Anti-Inflammatory & Antioxidants

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Curcumin / Turmeric

NF-κB inhibitor — potent anti-inflammatory, requires piperine for absorption

Astaxanthin

6000x more potent than Vitamin C — crosses blood-brain barrier, skin and eye health

NAC

N-Acetyl Cysteine — glutathione precursor for liver health and oxidative stress

600–1200mg/day

Foundational Health & Others

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Vitamin D3 + K2

Bone, immune & hormonal health

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Magnesium

Sleep, muscle, 300+ enzymes

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Collagen

Skin, joints, connective tissue

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Creatine

Muscle, brain, energy stores

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Probiotics

Gut microbiome, immunity

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Adaptogens

Stress resilience, hormones

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Shilajit

Mineral fulvic acid, mitochondria

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NAC & Glutathione

Antioxidant defense system